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Androgens, including TESTIM, may decrease concentrations of thyroxine-binding globulins, resulting in decreased total T4 serum concentrations and increased resin uptake of T3 and T4. Regular monitoring of serum calcium concentrations is recommended in these patients. Monitor the lipid profile periodically, particularly after starting testosterone therapy and after dose increases.
Testim® should not be used in patients with known hypersensitivity to any of its ingredients, including testosterone USP that is chemically synthesized from soy. Serious side effects include worsened symptoms of an enlarged prostate. Testim 1% (testosterone gel) is a prescription medicine that contains testosterone. Other side effects include more erections than are normal for you or erections that last a long time. You are encouraged to report negative side effects of prescription drugs to the FDA. The study was double-blind for the doses of TESTIM and placebo, but open-label for the non-scrotal testosterone transdermal system. When males wore a long-sleeved T-shirt and rubbing was started at 1 and at 4 hours after application, the transfer of testosterone from male to female partners was prevented.
Alternatively, testosterone products for women are available from compounding pharmacies in the United States, although such products are unregulated and manufacturing quality is not ensured. There are no testosterone products approved for use in women in the United States and many other countries. Other androgenic side effects, such as weight gain, pattern hair loss, and voice deepening, were also reported in some trials, but were excluded from analyses due to insufficient data. Women who were menopausal due to ovariectomy showed significantly greater improvement in sexual function with testosterone relative to those who had normal menopause. These domains included frequency of sexual activity, orgasm, arousal, and sexual satisfaction, among others.
Gynecomastia and breast tenderness may occur with high dosages of testosterone due to peripheral conversion of testosterone by aromatase into excessive amounts of the estrogen estradiol. Exogenous testosterone may cause suppression of spermatogenesis in men, leading to, in some cases, reversible infertility. In February 2025, the US Food and Drug Administration (FDA) specified label changes for products containing testosterone. Another approach being investigated is the detection of the administered form of testosterone, usually an ester, in hair. A number of methods for detecting testosterone use by athletes have been employed, most based on a urine test. This has proven contentious, with the Court of Arbitration for Sport suspending the IAAF policy due to insufficient evidence of a link between high androgen levels and improved athletic performance.
Individuals taking supratherapeutic doses of testosterone may experience withdrawal symptoms lasting for weeks or months, which include Serious adverse reactions have been reported in individuals who abuse anabolic androgenic steroids, and include Table 2 summarizes the mean testosterone concentrations on Day 30 for patients receiving TESTIM 50 mg or 100 mg. Figure 1 summarizes the 24-hour pharmacokinetic profile of testosterone for patients maintained on TESTIM 50 mg or TESTIM 100 mg for 30 days. Hypertension was observed in pregnant female rats and their offspring exposed to doses approximately twice those used for testosterone replacement therapy. The administration of exogenous testosterone has been reported to suppress spermatogenesis in the rat, dog, and non-human primates, which was reversible on cessation of the treatment. Secondary exposure to testosterone in children and women can occur with the use of testosterone gel in men.
Alcohol-based products, including TESTIM, are flammable; therefore, patients should be advised to avoid fire, flame or smoking until the TESTIM has dried. Free thyroid hormone concentrations remain unchanged, however, and there is no clinical evidence of thyroid dysfunction. Gynecomastia occasionally develops and occasionally persists in patients being treated for hypogonadism see ADVERSE REACTIONS. Edema, with or without congestive heart failure, may be a serious complication in patientswith preexisting cardiac, renal, or hepatic disease.

Female